Journal article
Localization of relaxin-3 in brain of Macaca fascicularis: Identification of a nucleus incertus in primate
S Ma, Q Sang, JL Lanciego, AL Gundlach
Journal of Comparative Neurology | WILEY | Published : 2009
DOI: 10.1002/cne.22197
Abstract
Relaxin-3 (RLN3) is a highly conserved, ancestral member of the insulin/relaxin peptide family. RLN3 mRNA is highly expressed in rat, mouse, and human brain and molecular genetic and pharmacological studies suggest that RLN3 is the cognate ligand for the relaxin family peptide-3 receptor (RXFP3). The distribution of RLN3/RXFP3 networks has been determined in rat and mouse brain, but not in higher species. In this study we describe the distribution of RLN3 neurons in the brain of macaque (Macaca fascicularis) using in situ hybridization histochemistry and immunohistochemistry. RLN3 mRNA and high levels of RLN3-like immunoreactivity (-LI) were observed in neurons within a ventromedial region o..
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Awarded by National Health and Medical Research Council of Australia
Awarded by Spanish Ministry of Science
Awarded by CIBERNED
Funding Acknowledgements
Grant sponsor: National Health and Medical Research Council of Australia; Grant numbers: 520299 (to S.M.), 277609 and 509246 (to A.L.G.); Grant sponsor: Collaborative research agreement with Johnson & Johnson Pharmaceutical Research & Development, San Diego, CA (to A.L.G.); Grant sponsor: Howard Florey Biomedical Foundation USA (to A.L.G.); Grant sponsor: Spanish Ministry of Science; Grant number BFU2006-06744 (to J.L.L.); Grant sponsor: CIBERNED; Grant number. CM06/05/006 (to J.L.L.); Grant sponsor. Fundacion de Investigacion Medica Mutua Madrilefia (to J.L.L.); Grant sponsor. UTE-project/FIMA (to J.L.L.); Grant sponsor: ANZ Trustees; Grant sponsor Ian Potter Foundation.